Leski, Tomasz A ORCID: 0000-0001-7688-9887, Bangura, Umaru ORCID: 0000-0001-8789-3187, Jimmy, David Henry, Ansumana, Rashid ORCID: 0000-0002-1973-7200, Lizewski, Stephen E, Stenger, David A, Taitt, Chris Rowe ORCID: 0000-0002-0125-9239 and Vora, Gary J ORCID: 0000-0002-0657-8597
(2013)
Multidrug-resistant tet(X)-containing hospital isolates in Sierra Leone.
International journal of antimicrobial agents, 42 (1).
pp. 83-86.
Text
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Abstract
The tet(X) gene encodes a flavin-dependent monooxygenase that confers resistance to all clinically relevant tetracycline antibiotics including tigecycline. It has only previously been identified in environmental and non-human pathogenic bacteria. To investigate levels of multidrug resistance in Bo, Sierra Leone, a molecular epidemiological study was conducted using an antimicrobial resistance determinant microarray (ARDM), PCR and DNA sequencing. The study found that 21% of isolates from Mercy Hospital (Bo, Sierra Leone) were tet(X)-positive, all of which originated from urinary specimens. Use of molecular epidemiological surveillance tools has provided the first evidence of tet(X)-containing multidrug-resistant Gram-negative hospital isolates in a hospital in Sierra Leone.
Item Type: | Article |
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Additional Information: | Available online 18 May 2013. Cite in press as: Leski TA, et al. Multidrug-resistant tet(X)-containing hospital isolates in Sierra Leone. Int J Antimicrob Agents (2013), http://dx.doi.org/10.1016/j.ijantimicag.2013.04.014 . Pages not for citation. 4 pages. |
Uncontrolled Keywords: | Humans, Bacteria, Bacterial Infections, Tetracyclines, DNA, Bacterial, Anti-Bacterial Agents, Microarray Analysis, Polymerase Chain Reaction, Drug Resistance, Multiple, Bacterial, Genes, Bacterial, Hospitals, Sierra Leone, Molecular Epidemiology |
Subjects: | ?? RM ?? |
Divisions: | Faculty of Health and Life Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 29 May 2013 15:57 |
Last Modified: | 16 Mar 2024 12:44 |
DOI: | 10.1016/j.ijantimicag.2013.04.014 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/11535 |