Understanding life and death decisions in human leukaemias

MacEwan, David J ORCID: 0000-0002-2879-0935, Barrera, Lawrence N, Keadsanti, Sujitra, Rushworth, Stuart A, Shah, Niraj M, Yuan, Tianma and Zaitseva, Lyubov (2014) Understanding life and death decisions in human leukaemias. BIOCHEMICAL SOCIETY TRANSACTIONS, 42 (4). pp. 747-751.

Text MacEwan et al Biochem Soc Trans.pdf - Published version Access to this file is embargoed until Unspecified. Download (239kB)

Abstract

Human leukaemia cells have an often unique ability to either undergo apoptotic cell death mechanisms or, at other times, undergo proliferative expansion, sometimes to the same stimulus such as the pluripotent cytokine TNFα (tumour necrosis factor α). This potential for life/death switching helps us to understand the molecular signalling machinery that underlies these cellular processes. Furthermore, looking at the involvement of these switching signalling pathways that may be aberrant in leukaemia informs us of their importance in cancer tumorigenesis and how they may be targeted pharmacologically to treat various types of human leukaemias. Furthermore, these important pathways may play a crucial role in acquired chemotherapy resistance and should be studied further to overcome in the clinic many drug-resistant forms of blood cancers. In the present article, we uncover the relationship that exists in human leukaemia life/death switching between the anti-apoptotic pro-inflammatory transcription factor NF-κB (nuclear factor κB) and the cytoprotective antioxidant-responsive transcription factor Nrf2 (nuclear factor-erythroid 2-related factor 2). We also discuss recent findings that reveal a major role for Btk (Bruton's tyrosine kinase) in both lymphocytic and myeloid forms of human leukaemias and lymphomas.

Item Type:	Article
Uncontrolled Keywords:	acute myeloid leukaemia (AML), anti-apoptotic agent, Bruton's tyrosine kinase (Btk), cytoprotective gene, life/death switching, transcription factor
Subjects:	?? RM ??
Depositing User:	Symplectic Admin
Date Deposited:	05 Dec 2014 15:11
Last Modified:	15 Dec 2022 12:31
DOI:	10.1042/BST20140127
Publisher's Statement :	This research was originally published in BiochemicalSociety Transactions. David J. MacEwan, Lawrence N. Barrera, Sujitra Keadsanti, Stuart A. Rushworth, Niraj M. Shah, Tianma Yuan and Lyubov Zaitseva. BiochemicalSociety Transactions 2014 Volume 42 747-751 © The Authors Journal compilation © �2014 Biochemical Society
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2003002