Ahmed, Muhammad S 
ORCID: 0000-0001-6163-8102, Jacques, Laura C, Mahallawi, Waleed, Ferrara, Francesca, Temperton, Nigel, Upile, Nay, Vaughan, Casey, Sharma, Ravi, Beer, Helen, Hoschler, Katja et al (show 2 more authors)
(2015)
Cross-reactive immunity against influenza viruses in children and adults following 2009 pandemic H1N1 infection.
ANTIVIRAL RESEARCH, 114.
pp. 106-112.
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Abstract
<h4>Unlabelled</h4>2009 H1N1 pandemic influenza (A(H1N1)pdm09) virus infected large numbers of people worldwide. Recent studies suggest infection with A(H1N1)pdm09 virus elicited cross-reactive anti-hemagglutinin (HA) memory B cell response to conserved regions of HA. However, the breadth and magnitude of cross-reactive immunity in children and adults following A(H1N1)pdm09 infection are unknown.<h4>Methods</h4>We investigated serum anti-HA immunity to a number of group-1 and -2 viruses in children and adults using hemagglutination inhibition (HAI), enzyme-linked immunosorbent assay and virus neutralization assay.<h4>Results</h4>Applying hemagglutination inhibition (HAI) titers ⩾40 against A(H1N1)pdm09 as threshold of sero-positivity, we observed significantly higher levels of anti-HA antibodies to a number of virus subtypes, including those neutralizing H5N1, in subjects with HAI titer ⩾40 than those with HAI <40. Adults demonstrated broader and stronger cross-reactive anti-HA antibodies than children, including cross-reactive anti-HA1 and -HA2 antibodies. By comparison, individuals with serologic evidence of recent exposure to seasonal H1N1 or H3N2 did not show such broad cross-reactive immunity.<h4>Conclusion</h4>Our results suggest individuals exposed to A(H1N1)pdm09 virus developed a broad and age-associated cross-reactive anti-HA immunity which may have important implications for future vaccination strategies to enable protection against a broader range of influenza viruses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Influenza virus, Pandemic H1N1 infection, Serum antibody, Cross-reactive immunity, Anti-hemagglutinin antibody, Virus neutralization |
| Subjects: | ?? QR ?? ?? QR180 ?? ?? QR355 ?? ?? R1 ?? ?? RA ?? ?? RA0421 ?? ?? RF ?? ?? RJ ?? ?? RJ101 ?? |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 08 Jan 2015 10:14 |
| Last Modified: | 16 Dec 2022 12:20 |
| DOI: | 10.1016/j.antiviral.2014.12.008 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/2004540 |
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