Modulation of phosphatidylinositol 4-phosphate levels by CaBP7 controls cytokinesis in mammalian cells



Rajamanoharan, Dayani, Mccue, Hannah V, Burgoyne, Robert D ORCID: 0000-0002-9219-0387 and Haynes, Lee P ORCID: 0000-0002-1296-0338
(2015) Modulation of phosphatidylinositol 4-phosphate levels by CaBP7 controls cytokinesis in mammalian cells. MOLECULAR BIOLOGY OF THE CELL, 26 (8). pp. 1428-1439.

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Abstract

Calcium and phosphoinositide signaling regulate cell division in model systems, but their significance in mammalian cells is unclear. Calcium-binding protein-7 (CaBP7) is a phosphatidylinositol 4-kinaseIIIβ (PI4KIIIβ) inhibitor required during cytokinesis in mammalian cells, hinting at a link between these pathways. Here we characterize a novel association of CaBP7 with lysosomes that cluster at the intercellular bridge during cytokinesis in HeLa cells. We show that CaBP7 regulates lysosome clustering and that PI4KIIIβ is essential for normal cytokinesis. CaBP7 depletion induces lysosome mislocalization, extension of intercellular bridge lifetime, and cytokinesis failure. These data connect phosphoinositide and calcium pathways to lysosome localization and normal cytokinesis in mammalian cells.

Item Type: Article
Additional Information: Copyright © 2015 by The American Society for Cell Biology.
Uncontrolled Keywords: Hela Cells, Lysosomes, Humans, Phosphatidylinositol Phosphates, Calcium-Binding Proteins, Signal Transduction, Cytokinesis
Depositing User: Symplectic Admin
Date Deposited: 15 Apr 2015 10:48
Last Modified: 15 Dec 2022 11:54
DOI: 10.1091/mbc.E14-07-1243
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/2009967

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