Immune responses and interactions following simultaneous application of live Newcastle disease, infectious bronchitis and avian metapneumovirus vaccines in specific-pathogen-free chicks

Awad, Faez, Forrester, Anne, Baylis, Matthew ORCID: 0000-0003-0335-187X, Lemiere, Stephane, Jones, Richard and Ganapathy, Kannan ORCID: 0000-0002-9401-3560 (2015) Immune responses and interactions following simultaneous application of live Newcastle disease, infectious bronchitis and avian metapneumovirus vaccines in specific-pathogen-free chicks. RESEARCH IN VETERINARY SCIENCE, 98. pp. 127-133.

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Abstract

Interactions between live Newcastle disease virus (NDV), avian metapneumovirus (aMPV) and infectious bronchitis virus (IBV) vaccines following simultaneous vaccination of day old specific pathogen free (SPF) chicks were evaluated. The chicks were divided into eight groups: seven vaccinated against NDV, aMPV and IBV (single, dual or triple) and one unvaccinated as control. Haemagglutination inhibition (HI) NDV antibody titres were similar across all groups but were above protective titres. aMPV vaccine when given with other live vaccines suppressed levels of aMPV enzyme-linked immunosorbent assay (ELISA) antibodies. Cellular and local immunity induced by administration of NDV, aMPV or IBV vaccines (individually or together) showed significant increase in CD4+, CD8+ and IgA bearing B-cells in the trachea compared to the unvaccinated group. Differences between the vaccinated groups were insignificant. Simultaneous vaccination with live NDV, aMPV and IBV did not affect the protection conferred against aMPV or IBV.

Item Type:	Article
Uncontrolled Keywords:	Chick, Vaccines, Interactions, Immune responses, NDV, aMPV, IBV
Depositing User:	Symplectic Admin
Date Deposited:	20 Apr 2015 08:47
Last Modified:	15 Dec 2022 11:52
DOI:	10.1016/j.rvsc.2014.11.004
Publisher's Statement :	NOTICE: this is the author’s version of a work that was accepted for publication in Research in Veterinary Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Research in Veterinary Science, [98, 2014] DOI: 10.1016/j.rvsc.2014.11.004
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2010157