Genome-wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs

Baird, AEG, Carter, SD ORCID: 0000-0002-3585-9400, Innes, JF, Ollier, W and Short, A (2014) Genome-wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs. ANIMAL GENETICS, 45 (4). pp. 542-549.

Text Baird_et_al-2014-Animal_Genetics.pdf - Unspecified Access to this file is embargoed until Unspecified. Download (531kB)

Abstract

Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome-wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by Sequenom genotyping in a further cohort of Newfoundlands (n = 271). The results, particularly SNPs identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR.

Item Type:	Article
Uncontrolled Keywords:	cranial cruciate ligament rupture, Newfoundlands, population stratification
Depositing User:	Symplectic Admin
Date Deposited:	20 May 2015 09:51
Last Modified:	15 Dec 2022 16:24
DOI:	10.1111/age.12162
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2011537