Impact of pseudomonas aeruginosa Liverpool epidemic strain (LES) on cystic fibrosis patients



Ashish, Abdul
Impact of pseudomonas aeruginosa Liverpool epidemic strain (LES) on cystic fibrosis patients. Doctor of Medicine thesis, University of Liverpool.

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Abstract

Cystic Fibrosis (CF) is the commonest life limiting inherited disease illness in the western world. Over the last few decades there have been many advances in the diagnosis and management of this condition. Patients born with the disease now are living into their fourth decade, which is a statement to the progress made over time. Along with the progress there have been new challenges in the world of CF. In the last two decades there have been several studies reporting the presence of transmissible Pseudomonas Aeruginosa (Psa) strains in CF clinics worldwide. The first one to be reported in UK Liverpool paediatric clinic was later identified as the Liverpool Epidemic Strain (LES). Previous studies have demonstrated chronic infection with LES can result in accelerated fall in lung function, increased hospitalisation and antibiotic requirements. This thesis looks at the effect of chronic infection of adults with CF and its implications on healthcare institutions caring for such patients. In particular on an individual level i investigated the health related quality of life associated with patients chronically infected with LES and compared it those with unique or no Psa strains. I have demonstrated that chronic infection with LES strain significantly worsens health related quality of life compared to those with unique or no Psa strains. Patients infected by transmissible Psa strains had worse physical functioning, respiratory symptoms, treatment burden, vitality, role, health perception and emotion than those with unique Psa strains (p

Item Type: Thesis (Doctor of Medicine)
Additional Information: Date: 2015-08 (completed)
Subjects: ?? QR ??
Depositing User: Symplectic Admin
Date Deposited: 19 Jan 2016 14:07
Last Modified: 16 Dec 2022 04:43
DOI: 10.17638/02026659
URI: https://livrepository.liverpool.ac.uk/id/eprint/2026659