Identification and characterisation of a set of differentially expressed genes from Glossina morsitans morsitans refractory to a trypanosome infection

Ejeh, Nicholas (2015) Identification and characterisation of a set of differentially expressed genes from Glossina morsitans morsitans refractory to a trypanosome infection. PhD thesis, University of Liverpool.

Text EjehNic_Jul2015_2039099.pdf.pdf - Unspecified Available under License Creative Commons Attribution. Download (5MB)

Abstract

Tsetse flies (Diptera: Glossinidae) are the vectors of African trypanosomiasis, a parasitic disease of humans and other animals that can be fatal if untreated. Trypanosomes undergo a complex life cycle in the fly involving a series of morphological and biochemical changes that culminate in the development of mammalian infective metacyclics in the salivary glands (Trypanosoma brucei) or the mouthparts (T. congolense). Once in the fly’s midgut, the stumpy forms, which are thought to be pre-adapted for life in the tsetse midgut, differentiate into the procyclic form. However, the majority of flies can effectively get rid of parasites before they develop or establish an infection in the midgut. One would expect that as a result of the high disease burden in Africa, there would be a corresponding large number of flies that are also infected, yet paradoxically, just very few number of flies (

Item Type:	Thesis (PhD)
Additional Information:	Date: 2015-07 (completed)
Divisions:	Faculty of Health and Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	01 Sep 2016 13:04
Last Modified:	17 Dec 2022 02:11
DOI:	10.17638/02039099
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2039099