Structural and functional studies of CARP and titin N2A protein complexes involved in the stress-response of muscle to apoptotic stimuli

Zhou, Tiankun (2015) Structural and functional studies of CARP and titin N2A protein complexes involved in the stress-response of muscle to apoptotic stimuli. Master of Philosophy thesis, University of Liverpool.

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Abstract

The cardiac ankyrin repeat protein (CARP) has been reported to bind to the N2A region of the giant sarcomeric protein titin. The interaction allegedly plays a role in preventing cardiomyocyte apoptosis, thereby protecting against heart failure (HF). The latter is now a leading cause of mortality in the developed world. In this work, we focus on CARP to guide future functional studies that can clarify its significance in heart disease.

Item Type:	Thesis (Master of Philosophy)
Additional Information:	Date: 2015-12-21 (completed)
Divisions:	Faculty of Health and Life Sciences > Faculty of Health and Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	01 Sep 2016 13:38
Last Modified:	17 Dec 2022 02:13
DOI:	10.17638/02043799
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2043799