Persistent Endothelial Activation and Inflammation After <i>Plasmodium falciparum</i> Infection in Malawian Children


Moxon, Christopher A, Chisala, Ngawina V, Wassmer, Samuel C, Taylor, Terrie E, Seydel, Karl B, Molyneux, Malcolm E, Faragher, Brian, Kennedy, Neil, Toh, Cheng-Hock, Craig, Alister G ORCID: 0000-0003-0914-6164 et al (show 1 more authors) (2014) Persistent Endothelial Activation and Inflammation After <i>Plasmodium falciparum</i> Infection in Malawian Children. JOURNAL OF INFECTIOUS DISEASES, 209 (4). pp. 610-615.

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Abstract

Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits. These vascular changes may represent a previously unrecognized contributor to ongoing malaria-associated morbidity and mortality.

Item Type: Article
Additional Information: PMID:24048963## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords: Plasmodium falciparum, pathogen burden, endothelial activation, endothelial dysfunction, inflammation, cardiovascular disease, stroke, pediatric
Depositing User: Symplectic Admin
Date Deposited: 15 Apr 2016 09:23
Last Modified: 05 Oct 2023 11:35
DOI: 10.1093/infdis/jit419
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3000574
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