Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action

Fernandez-Alvaro, Elena, Hong, W David, Nixon, Gemma L, O'Neil, Paul M and Calderon, Felix (2016) Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action. JOURNAL OF MEDICINAL CHEMISTRY, 59 (12). pp. 5587-5603.

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Official URL: http://dx.doi.org/10.1021/acs.jmedchem.5b01485

Abstract

Natural products have played a pivotal role in malaria chemotherapy progressing from quinine and artemisinin to ozonide-based compounds. Many of these natural products have served as template for the design and development of antimalarial drugs currently in the clinic or in the development phase. In this review, we will detail those privileged scaffolds that have guided medicinal chemistry efforts yielding molecules that have reached the clinic.

Item Type:	Article
Uncontrolled Keywords:	Humans, Malaria, Biological Products, Antimalarials, Molecular Structure, Chemistry, Pharmaceutical
Depositing User:	Symplectic Admin
Date Deposited:	27 Apr 2016 15:46
Last Modified:	19 Jan 2023 07:37
DOI:	10.1021/acs.jmedchem.5b01485
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3000668