The synthesis and biological evaluation of a kabiramide C fragment modified with a WH2 consensus actin-binding motif as a potential disruptor of the actin cytoskeleton

Tetlow, Daniel J, Winder, Steve J and Aissa, Christophe ORCID: 0000-0003-0750-9435 (2016) The synthesis and biological evaluation of a kabiramide C fragment modified with a WH2 consensus actin-binding motif as a potential disruptor of the actin cytoskeleton. CHEMICAL COMMUNICATIONS, 52 (4). pp. 807-810.

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Official URL: http://dx.doi.org/10.1039/c5cc06081h

Abstract

The F-actin depolymerisation potency of a fragment of kabiramide C was increased when modified with a WH2 consensus actin-binding motif LKKV. Despite its low affinity for actin monomers, a shorter analogous fragment not bearing LKKV was identified as a potent inhibitor of actin polymerisation and a promoter of its depolymerisation, resulting in a loss of actin stress fibres in cells.

Item Type:	Article
Uncontrolled Keywords:	Oxazoles, Biological Factors, Amino Acid Sequence, Protein Structure, Tertiary, Protein Binding, Actin Cytoskeleton
Depositing User:	Symplectic Admin
Date Deposited:	09 May 2016 09:57
Last Modified:	19 Jan 2023 07:37
DOI:	10.1039/c5cc06081h
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3001134