Wilding, JPH 
ORCID: 0000-0003-2839-8404, Overgaard, RV, Jacobsen, LV, Jensen, CB and le Roux, CW
(2016)
Exposure-response analyses of liraglutide 3.0 mg for weight management.
Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics, 18 (5).
pp. 491-499.
Abstract
Aims Liraglutide 3.0 mg, an acylated GLP‐1 analogue approved for weight management, lowers body weight through decreased energy intake. We conducted exposure‐response analyses to provide important information on individual responses to given drug doses, reflecting inter‐individual variations in drug metabolism, absorption and excretion. Methods We report efficacy and safety responses across a wide range of exposure levels, using data from one phase II (liraglutide doses 1.2, 1.8, 2.4 and 3.0 mg), and two phase IIIa [SCALE O besity and P rediabetes (3.0 mg); SCALE D iabetes (1.8; 3.0 mg)] randomized, placebo‐controlled trials (n = 4372). Results There was a clear exposure–weight loss response. Weight loss increased with greater exposure and appeared to level off at the highest exposures associated with liraglutide 3.0 mg in most individuals, but did not fully plateau in men. In individuals with overweight/obesity and comorbid type 2 diabetes, there was a clear exposure–glycated haemoglobin (HbA1c ) relationship. HbA1c reduction increased with higher plasma liraglutide concentration (plateauing at ∼21 nM ); however, for individuals with baseline HbA1c >8.5%, HbA1c reduction did not fully plateau. No exposure–response relationship was identified for any safety outcome, with the exception of gastrointestinal adverse events (AEs ). Individuals with gallbladder AEs , acute pancreatitis or malignant/breast/benign colorectal neoplasms did not have higher liraglutide exposure compared with the overall population. Conclusions These analyses support the use of liraglutide 3.0 mg for weight management in all subgroups investigated; weight loss increased with higher drug exposure, with no concomitant deterioration in safety/tolerability besides previously known gastrointestinal side effects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | body weight, glucagon-like peptide-1, incretin, pharmacokinetic |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 03 Jun 2016 08:57 |
| Last Modified: | 19 Jan 2023 07:36 |
| DOI: | 10.1111/dom.12639 |
| Open Access URL: | http://onlinelibrary.wiley.com/enhanced/doi/10.111... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3001495 |
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