Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges



Ferrand, Rashida A, Briggs, Datonye, Ferguson, Jane, Penazzato, Martina, Armstrong, Alice, MacPherson, Peter ORCID: 0000-0002-0329-9613, Ross, David A and Kranzer, Katharina
(2016) Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 21 (3). pp. 325-333.

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Abstract

<h4>Objective</h4>Medication adherence is often suboptimal for adolescents with HIV, and establishing correct weight-based antiretroviral therapy dosing is difficult, contributing to virological failure. This review aimed to determine the proportion of adolescents achieving virological suppression after initiating ART.<h4>Methods</h4>MEDLINE, EMBASE and Web of Science databases were searched. Studies published between January 2004 and September 2014 including ≥50 adolescents taking ART and reporting on the proportion of virological suppressed participants were included.<h4>Results</h4>From a total of 5316 potentially relevant citations, 20 studies were included. Only eight studies reported the proportion of adolescents that were virologically suppressed at a specified time point. The proportion of adolescents with virological suppression at 12 months ranged from 27 to 89%.<h4>Conclusion</h4>Adolescent achievement of HIV virological suppression was highly variable. Improved reporting of virological outcomes from a wider range of settings is required to support efforts to improve HIV care and treatment for adolescents.

Item Type: Article
Uncontrolled Keywords: Adolescents, HIV, virological suppression, adolescents, VIH, suppression virologique, Adolescentes, VIH, supresion virologica
Depositing User: Symplectic Admin
Date Deposited: 08 Jun 2016 14:16
Last Modified: 19 Jan 2023 07:35
DOI: 10.1111/tmi.12656
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3001594