The effects of dose and diet on the pharmacokinetics of omeprazole in the horse

Sykes, BW, Underwood, C, McGowan, CM ORCID: 0000-0002-1946-9584 and Mills, PC (2017) The effects of dose and diet on the pharmacokinetics of omeprazole in the horse. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40 (2). pp. 172-178.

Text PK Manuscript - author accepted.docx - Author Accepted Manuscript Download (188kB)

Abstract

This study aimed to investigate the effect of diet and dose on the pharmacokinetics of omeprazole in the horse. Six horses received two doses (1 and 4 mg/kg) of omeprazole orally once daily for 5 days. Each dose was evaluated during feeding either a high-grain/low-fibre (HG/LF) diet or an ad libitum hay (HAY) diet in a four-way crossover design. Plasma samples were collected for pharmacokinetic analysis on days 1 and 5. Plasma omeprazole concentrations were determined by ultra-high pressure liquid chromatography-mass spectrometry. In horses being fed the HG/LF diet, on day 1, the area under the curve (AUC) and maximal plasma concentration (C_max ) were higher on the 4 mg/kg dose than on the 1 mg/kg dose. The AUC was higher on day 5 compared to day 1 with the 4 mg/kg dose on the HG/LF diet. On days 1 and 5, the AUC and C_max were higher in horses being fed the HG/LF diet and receiving the 4 mg/kg dose than in horses being fed the HAY diet and receiving the 1 mg/kg dose. These findings suggest that both dose and diet may affect pharmacokinetic variables of omeprazole in the horse.

Item Type:	Article
Uncontrolled Keywords:	Animals, Horses, Omeprazole, Anti-Ulcer Agents, Diet, Drug Administration Schedule, Area Under Curve, Cross-Over Studies, Dose-Response Relationship, Drug, Half-Life, Animal Feed
Depositing User:	Symplectic Admin
Date Deposited:	02 Sep 2016 14:12
Last Modified:	19 Jan 2023 07:30
DOI:	10.1111/jvp.12345
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3003156