Winstanley, Craig ORCID: 0000-0002-2662-8053, O'Brien, Siobhan ORCID: 0000-0003-2741-6172 and Brockhurst, Michael A
(2016)
<i>Pseudomonas aeruginosa</i> Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections.
TRENDS IN MICROBIOLOGY, 24 (5).
pp. 327-337.
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Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections.pdf - Published version Download (1MB) |
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Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections.pdf - Published version Download (1MB) |
Abstract
Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation during chronic infection of the cystic fibrosis (CF) lung, including reduced production of virulence factors, transition to a biofilm-associated lifestyle, and evolution of high-level antibiotic resistance. Populations of P. aeruginosa in chronic CF lung infections typically exhibit high phenotypic diversity, including for clinically important traits such as antibiotic resistance and toxin production, and this diversity is dynamic over time, making accurate diagnosis and treatment challenging. Population genomics studies reveal extensive genetic diversity within patients, including for transmissible strains the coexistence of highly divergent lineages acquired by patient-to-patient transmission. The inherent spatial structure and spatial heterogeneity of selection in the CF lung appears to play a key role in driving P. aeruginosa diversification.
Item Type: | Article |
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Uncontrolled Keywords: | Humans, Pseudomonas aeruginosa, Pseudomonas Infections, Cystic Fibrosis, Chronic Disease, Virulence Factors, Adaptation, Biological, Genetic Variation, Biological Evolution |
Depositing User: | Symplectic Admin |
Date Deposited: | 26 Jan 2017 09:32 |
Last Modified: | 17 Oct 2023 01:10 |
DOI: | 10.1016/j.tim.2016.01.008 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3003995 |