Decoding RAS isoform and codon-specific signalling



Newlaczyl, Anna U, Hood, Fiona E, Coulson, Judy M ORCID: 0000-0003-2191-2001 and Prior, Ian A ORCID: 0000-0002-4055-5161
(2014) Decoding RAS isoform and codon-specific signalling. BIOCHEMICAL SOCIETY TRANSACTIONS, 42 (4). pp. 742-746.

[img] Text
Decoding RAS isoform and codon-specific signalling.pdf - Published version

Download (281kB)

Abstract

RAS proteins are key signalling hubs that are oncogenically mutated in 30% of all cancer cases. Three genes encode almost identical isoforms that are ubiquitously expressed, but are not functionally redundant. The network responses associated with each isoform and individual oncogenic mutations remain to be fully characterized. In the present article, we review recent data defining the differences between the RAS isoforms and their most commonly mutated codons and discuss the underlying mechanisms.

Item Type: Article
Additional Information: ## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords: cancer, GTPase, HRAS, KRAS, NRAS
Depositing User: Symplectic Admin
Date Deposited: 17 Nov 2016 09:38
Last Modified: 19 Jan 2023 07:25
DOI: 10.1042/BST20140057
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3004550