Gianfrancesco, O ORCID: 0000-0002-1613-5247, Warburton, A, Collier, DA, Bubb, VJ ORCID: 0000-0003-2763-7004 and Quinn, JP ORCID: 0000-0003-3551-7803
(2017)
Novel brain expressed RNA identified at the MIR137 schizophrenia-associated locus.
Schizophrenia Research, 184.
pp. 109-115.
Text
SUBMISSION 23.11 Novel brain expressed RNA.docx - Author Accepted Manuscript Download (2MB) |
Abstract
Genome-wide association studies (GWAS) have identified a locus on chromosome 1p21.3 to be highly associated with schizophrenia. A microRNA, MIR137, within this locus has been proposed as the gene causally associated with schizophrenia, due to its known role as a regulator of neuronal development and function. However, the involvement of other genes within this region, including DPYD (dihydropyrimidine dehydrogenase), is also plausible. In this communication, we describe a previously uncharacterised, brain-expressed RNA, EU358092, within the schizophrenia-associated region at 1p21.3. As we observed for MIR137, EU358092 expression was modulated in response to psychoactive drug treatment in the human SH-SY5Y neuroblastoma cell line. Bioinformatic analysis of publically available CNS expression data indicates that MIR137 and EU358092 are often co-expressed in vivo. A potential regulatory domain for expression of EU358092 is identified by bioinformatic analysis and its regulatory function is confirmed by reporter gene assays. These data suggest a potentially important role for EU358092 in the aetiology of schizophrenia, either individually or in combination with other genes at this locus.
Item Type: | Article |
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Uncontrolled Keywords: | EU358092, lncRNA, microRNA-137, Schizophrenia |
Depositing User: | Symplectic Admin |
Date Deposited: | 23 Nov 2016 17:06 |
Last Modified: | 19 Jan 2023 07:25 |
DOI: | 10.1016/j.schres.2016.11.034 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3004656 |