Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis



Skyler, Jay S, Bakris, George L, Bonifacio, Ezio, Darsow, Tamara, Eckel, Robert H, Groop, Leif, Groop, Per-Henrik, Handelsman, Yehuda, Insel, Richard A, Mathieu, Chantal
et al (show 7 more authors) (2017) Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis. DIABETES, 66 (2). pp. 241-255.

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Abstract

The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, "The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and progression, as well as complications. The participants debated how to determine appropriate therapeutic approaches based on disease pathophysiology and stage and defined remaining research gaps hindering a personalized medical approach for diabetes to drive the field to address these gaps. The authors recommend a structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment.

Item Type: Article
Uncontrolled Keywords: Humans, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetes Complications, Disease Progression, Hypoglycemic Agents, Prognosis, Risk Factors, Genotype, Phenotype, Precision Medicine
Depositing User: Symplectic Admin
Date Deposited: 04 Jan 2017 08:55
Last Modified: 19 Jan 2023 07:23
DOI: 10.2337/db16-0806
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3005060