Chan, Anthony WH, Chong, Charing CN, Mo, Frankie KF, Wong, John, Yeo, Winnie, Johnson, Philip J 
ORCID: 0000-0003-1404-0209, Yu, Shuangni, Lai, Paul BS, Chan, Anthony TC, To, Ka-Fai et al (show 1 more authors)
(2016)
Applicability of albumin-bilirubin-based Japan integrated staging score in hepatitis B-associated hepatocellular carcinoma.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 31 (10).
pp. 1766-1772.
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Abstract
<h4>Background and aim</h4>The Japan Integrated Staging (JIS) for hepatocellular carcinoma (HCC) has been extensively studied in hepatitis virus C-endemic Japanese population but seldom evaluated outside Japan, while albumin-bilirubin (ALBI)-based JIS (ALBI-T) has never been externally validated. We evaluate the prognostic significance of the ALBI-T score among Chinese patients with hepatitis virus B (HBV)-related HCC, and to explore its potential therapeutic application in selecting patients for appropriate treatments in addition to the Barcelona Clinic Liver Cancer (BCLC) recommendation.<h4>Methods</h4>A cohort of 1222 HBV-associated HCC patients was evaluated to compare the prognostic performance of JIS and ALBI-T scores by homogeneity likelihood chi-square and corrected Akaike information criterion. In the subgroup analysis of each BCLC stage, Kaplan-Meier method and log-rank statistics were used to compare overall survival of patients undergoing different treatment options.<h4>Results</h4>The ALBI-T score showed better prognostic performance than the JIS score, which were indicated by homogeneity likelihood chi-squares (ALBI-T 580.12 vs JIS 536.35) and Akaike information criteria (ALBI-T 9836.57 vs JIS 9880.23). Treatment options significantly influenced prognosis among patients of the same BCLC stage. With the use of ALBI-T score 4 as the cutoff, the current study identified that a portion of patients (14.7%, 25.2% and 28.6% of BCLC stage B, C and D, respectively) undergoing unnecessary therapy without survival advantage.<h4>Conclusions</h4>The ALBI-T score is applicable to Chinese patients with HBV-related HCC to provide reasonable prognostic information as well as potentially helping clinicians to avoid offering non-beneficial aggressive treatments.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Barcelona Clinic Liver Cancer (BCLC), liver neoplasm, staging, survival |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 02 Mar 2017 08:28 |
| Last Modified: | 19 Jan 2023 07:20 |
| DOI: | 10.1111/jgh.13339 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3005161 |
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