A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

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Raffan, E, Dennis, RJ, O'Donovan, CJ, Becker, JM, Scott, RA, Smith, SP, Withers, DJ, Wood, CJ, Conci, E, Clements, DN et al (show 12 more authors) , Summers, KM, German, AJ ORCID: 0000-0002-3017-7988, Mellersh, CS, Arendt, ML, Iyemere, VP, Withers, E, Söder, J, Wernersson, S, Andersson, G, Lindblad-Toh, K, Yeo, GSH and O'Rahilly, S (2016) A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. Cell Metabolism, 23 (5). pp. 893-900.

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Abstract

© 2016 The Authors.Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

Item Type:	Article
Uncontrolled Keywords:	COS Cells, Animals, Dogs, Obesity, Body Weight, Pro-Opiomelanocortin, beta-MSH, Receptors, Melanocortin, Feeding Behavior, Appetite, Gene Deletion, Amino Acid Sequence, Base Sequence, Base Pairing, Genotype, Adiposity, Chlorocebus aethiops
Depositing User:	Symplectic Admin
Date Deposited:	12 Jan 2017 15:04
Last Modified:	19 Jan 2023 07:20
DOI:	10.1016/j.cmet.2016.04.012
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3005211

Available Versions of this Item

• A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. (deposited 27 May 2016 07:56)
  • A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. (deposited 12 Jan 2017 15:04) [Currently Displayed]