Early Weight Loss with Liraglutide 3.0 mg Predicts 1-Year Weight Loss and is Associated with Improvements in Clinical Markers



Fujioka, Ken, O'Neil, Patrick M, Davies, Melanie, Greenway, Frank, Lau, David CW, Claudius, Birgitte, Skjoth, Trine Vang, Jensen, Christine Bjorn and Wilding, John PH ORCID: 0000-0003-2839-8404
(2016) Early Weight Loss with Liraglutide 3.0 mg Predicts 1-Year Weight Loss and is Associated with Improvements in Clinical Markers. OBESITY, 24 (11). pp. 2278-2288.

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Abstract

<h4>Objective</h4>To identify an early response criterion for predicting ≥5% weight loss with liraglutide 3.0 mg at week 56 and to compare efficacy outcomes in early responders (ERs) and early nonresponders (ENRs).<h4>Methods</h4>Using pooled data from the SCALE Obesity and Prediabetes and SCALE Diabetes trials, weight loss of ≥4% at 16 weeks best predicted ≥5% weight loss after 56 weeks. Weight loss and changes in cardiometabolic risk factors and health-related quality of life were evaluated in ERs (≥4% weight loss at week 16) and ENRs (<4% weight loss at week 16) completing 56 weeks' treatment.<h4>Results</h4>Proportions of ERs/ENRs to liraglutide 3.0 mg were 77.3%/22.7% (individuals without type 2 diabetes, T2D) and 62.7%/37.3% (those with T2D). Greater mean weight loss was observed in ERs versus ENRs: 10.8% versus 3.0% (without T2D) and 8.5% versus 3.1% (T2D). In both trials, greater proportions of ERs versus ENRs achieved ≥5%, >10%, and >15% weight loss at week 56 with liraglutide 3.0 mg. Greater improvements in cardiometabolic risk factors and health-related quality of life scores were observed in ERs versus ENRs.<h4>Conclusions</h4>The early response criterion was clinically useful to identify individuals who would achieve clinically meaningful weight loss at 56 weeks.

Item Type: Article
Uncontrolled Keywords: Respiratory System, Cardiovascular System, Humans, Prediabetic State, Obesity, Body Weight, Weight Loss, Anti-Obesity Agents, Body Mass Index, Treatment Outcome, Exercise, Endpoint Determination, Risk Factors, Double-Blind Method, Dose-Response Relationship, Drug, Quality of Life, Adult, Middle Aged, Female, Male, Biomarkers, Liraglutide
Depositing User: Symplectic Admin
Date Deposited: 01 Feb 2017 09:42
Last Modified: 19 Jan 2023 07:19
DOI: 10.1002/oby.21629
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3005492