Long-term follow-up of fenestrated endovascular repair for juxtarenal aortic aneurysm

Roy, IN ORCID: 0000-0001-9701-8319, Millen, AM, Jones, SM, Vallabhaneni, SR, Scurr, JRH, McWilliams, RG, Brennan, JA and Fisher, RK (2017) Long-term follow-up of fenestrated endovascular repair for juxtarenal aortic aneurysm. BRITISH JOURNAL OF SURGERY, 104 (8). pp. 1020-1027.

Text Manuscript.docx - Author Accepted Manuscript Download (1MB)

Abstract

<h4>Background</h4>Fenestrated endovascular aneurysm repair (FEVAR) is increasingly being used for juxtarenal aortic aneurysms. The aim of this study was to review long-term results and assess the importance of changing stent-graft design on outcomes.<h4>Methods</h4>This was a retrospective review of all patients who underwent FEVAR within a single unit over 12 years (February 2003 to December 2015). Kaplan-Meier analysis of survival, and freedom from target vessel loss, aneurysm expansion, graft-related endoleak and secondary intervention was performed. Comparison between outcomes of less complex grafts (fewer than 3 fenestrations) and more complex grafts (3 or 4 fenestrations) was undertaken.<h4>Results</h4>Some 173 patients underwent FEVAR; median age was 76 (i.q.r. 70-79) years and 90·2 per cent were men. Median aneurysm diameter was 63 (59-71) mm and median follow-up was 34 (16-50) months. The adjusted primary technical operative success rate was 95·4 per cent. The in-hospital mortality rate was 5·2 per cent; there was no known aneurysm-related death during follow-up. Median survival was 7·1 (95 per cent c.i. 5·2 to 8·1) years and overall survival was 60·1 per cent (104 of 173). There was a trend towards an increasing number of fenestrations in the graft design over time. In-hospital mortality appeared higher when more complex stent-grafts were used (8 versus 2 per cent for stent-grafts with 3-4 versus fewer than 3 fenestrations; P = 0·059). Graft-related endoleaks were more common following deployment of stent-grafts with three or four fenestrations (12 of 90 versus 6 of 83; P < 0·001).<h4>Conclusion</h4>Fenestrated endovascular aneurysm repair for juxtarenal aneurysm is associated with few aneurysm-related deaths in the long term. Significant numbers of secondary interventions are required, but the majority of these can be performed using an endovascular approach.

Item Type:	Article
Uncontrolled Keywords:	Humans, Aortic Aneurysm, Abdominal, Intraoperative Complications, Postoperative Complications, Surgical Wound Dehiscence, Aftercare, Length of Stay, Survival Analysis, Retrospective Studies, Prosthesis Design, Blood Vessel Prosthesis, Stents, Aged, Female, Male, Endovascular Procedures, Operative Time
Depositing User:	Symplectic Admin
Date Deposited:	09 Feb 2017 16:43
Last Modified:	19 Jan 2023 07:19
DOI:	10.1002/bjs.10524
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3005613