Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa.

Waters, EM, Neill, DR ORCID: 0000-0002-7911-8153, Kaman, B, Sahota, JS, Clokie, MRJ, Winstanley, C ORCID: 0000-0002-2662-8053 and Kadioglu, A ORCID: 0000-0003-1137-6321 (2017) Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa. Thorax, 72 (7). pp. 666-667.

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Official URL: http://dx.doi.org/10.1136/thoraxjnl-2016-209265

Abstract

With an increase in cases of multidrug-resistant Pseudomonas aeruginosa, alternative and adjunct treatments are needed, leading to renewed interest in bacteriophage therapy. There have been few clinically relevant studies of phage therapy against chronic lung infections. Using a novel murine model that uses a natural respiratory inhalation route of infection, we show that phage therapy is an effective treatment against chronic P. aeruginosa lung infections. We also show efficacy against P. aeruginosa in a biofilm-associated cystic fibrosis lung-like environment. These studies demonstrate the potential for phage therapy in the treatment of established and recalcitrant chronic respiratory tract infections.

Item Type:	Article
Uncontrolled Keywords:	Animals, Mice, Inbred BALB C, Mice, Biofilms, Pseudomonas aeruginosa, Pseudomonas Infections, Respiratory Tract Infections, Disease Models, Animal, Chronic Disease, Colony Count, Microbial, Time Factors, Phage Therapy
Depositing User:	Symplectic Admin
Date Deposited:	10 Mar 2017 10:43
Last Modified:	19 Jan 2023 07:14
DOI:	10.1136/thoraxjnl-2016-209265
Open Access URL:	http://thorax.bmj.com/content/thoraxjnl/early/2017...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3006315