Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application


Lee, Katie Joanna, Clegg, Peter David ORCID: 0000-0003-0632-0032, Comerford, Eithne Josephine ORCID: 0000-0002-5244-6042 and Canty-Laird, Elizabeth Gail ORCID: 0000-0001-5041-1316 (2017) Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application. STEM CELLS INTERNATIONAL, 2017. 1919845-.

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Abstract

Ligament is prone to injury and degeneration and has poor healing potential and, with currently ineffective treatment strategies, stem cell therapies may provide an exciting new treatment option. Ligament-derived stem cell (LDSC) populations have been isolated from a number of different ligament types with the majority of studies focussing on periodontal ligament. To date, only a few studies have investigated LDSC populations in other types of ligament, for example, intra-articular ligaments; however, this now appears to be a developing field. This literature review aims to summarise the current information on nondental LDSCs including <i>in vitro</i> characteristics of LDSCs and their therapeutic potential. The stem cell niche has been shown to be vital for stem cell survival and function in a number of different physiological systems; therefore, the LDSC niche may have an impact on LDSC phenotype. The role of the LDSC niche on LDSC viability and function will be discussed as well as the therapeutic potential of LDSC niche modulation.

Item Type: Article
Uncontrolled Keywords: Regenerative Medicine, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human
Depositing User: Symplectic Admin
Date Deposited: 21 Apr 2017 13:18
Last Modified: 15 Mar 2024 01:05
DOI: 10.1155/2017/1919845
Open Access URL: https://doi.org/10.1155/2017/1919845
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3007056

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