Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study



Finotello, R ORCID: 0000-0002-1932-211X, Vasconi, ME, Sabattini, S, Agnoli, C, Giacoboni, C, Annoni, M, Dentini, A, Bettini, G, Guazzi, P, Stefanello, D
et al (show 5 more authors) (2018) Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study. VETERINARY AND COMPARATIVE ONCOLOGY, 16 (1). pp. 159-166.

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Abstract

Feline large granular lymphocyte (LGL) lymphoma is an uncommon subtype of lymphoma characterized by a grave prognosis and scarce response to chemotherapy. There are limited reports on clinico-pathological and prognostic factors. One-hundred and 9 cats with newly diagnosed LGL lymphoma that underwent initial staging (including hematology, serum biochemistry, thoracic radiographs and abdominal ultrasound), and followed-up were retrospectively evaluated. LGL lymphoma was localized within the gastrointestinal tract with or without extra-intestinal involvement in 91.7% of the cases, and at extra-gastrointestinal sites in 8.3%. Symptoms were frequent. Anemia (31.2%) and neutrophilia (26.6%) were commonly observed, and 14 (12.8%) cats had neoplastic circulating cells. Frequent biochemistry abnormalities included elevated ALT (39.4%) and hypoalbuminemia (28.4%). Twenty (54.1%) of 37 cats had elevated serum LDH. Treatment varied among cats, and included surgery (11%), chemotherapy (23%), corticosteroids (38.5%) and no treatment (27.5%). Median time to progression (MTTP) was 5 days, and median survival time (MST) 21 days. MST was significantly shorter in the case of substage b, circulating neoplastic cells, lack of chemotherapy administration, and lack of treatment response. A small subset of cats (7.3%) survived more than 6 months, suggesting that a more favorable clinical course can be found among LGL lymphoma patients.

Item Type: Article
Uncontrolled Keywords: feline, large granular lymphocyte, LGL, lymphoma, prognosis
Depositing User: Symplectic Admin
Date Deposited: 30 May 2017 06:27
Last Modified: 19 Jan 2023 07:03
DOI: 10.1111/vco.12325
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3007702