Adverse effects of carbamazepine monotherapy among patients in Nigeria: a pilot study and implications

Olusanya, Adedunni, Ogunleye, Olayinka, Godman, Brian ORCID: 0000-0001-6539-6972, Fadare, Joseph and Danesi, Mustafa (2017) Adverse effects of carbamazepine monotherapy among patients in Nigeria: a pilot study and implications. JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH, 6 (1). pp. 33-42.

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Abstract

<h4>Aim</h4>Antiepileptic drugs do cause adverse effects, affecting patients' quality of life, adherence and seizures. Consequently, there is a need to study this among Nigerian patients.<h4>Methods</h4>Descriptive cross-sectional study assessing the extent of adverse effects with carbamazepine monotherapy and potential factors.<h4>Results</h4>54 patients (64.3%) reported no adverse effects, while 30 did. The most common adverse effects were memory problems followed by headaches, restlessness, tiredness and depression. Adverse effects were significantly higher in females, with females with low educational levels having significantly higher rates. Dose, co-medications, seizure control and comorbid conditions did not significantly affect adverse effects.<h4>Conclusion</h4>Perception of adverse effects was common in patients on carbamazepine monotherapy, more common in women than men. Educational status was important in women.

Item Type:	Article
Uncontrolled Keywords:	adverse events, carbamazepine, epilepsy, Nigeria
Depositing User:	Symplectic Admin
Date Deposited:	08 Jun 2017 06:31
Last Modified:	21 Feb 2023 08:45
DOI:	10.2217/cer-2016-0057
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3007855