Designing a bio-inspired biomimetic <i>in vitro</i> system for the optimization of <i>ex vivo</i> studies of pancreatic cancer



Totti, Stella, Vernardis, Spyros I, Meira, Lisiane, Perez-Mancere, Pedro A, Costello, Eithne, Greenhalf, William ORCID: 0000-0002-1865-3195, Palmer, Daniel ORCID: 0000-0002-7147-5703, Neoptolemos, John, Mantalaris, Athanasios and Velliou, Eirini G
(2017) Designing a bio-inspired biomimetic <i>in vitro</i> system for the optimization of <i>ex vivo</i> studies of pancreatic cancer. DRUG DISCOVERY TODAY, 22 (4). pp. 690-701.

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Abstract

Pancreatic cancer is one of the most aggressive and lethal human malignancies. Drug therapies and radiotherapy are used for treatment as adjuvants to surgery, but outcomes remain disappointing. Advances in tissue engineering suggest that 3D cultures can reflect the in vivo tumor microenvironment and can guarantee a physiological distribution of oxygen, nutrients, and drugs, making them promising low-cost tools for therapy development. Here, we review crucial structural and environmental elements that should be considered for an accurate design of an ex vivo platform for studies of pancreatic cancer. Furthermore, we propose environmental stress response biomarkers as platform readouts for the efficient control and further prediction of the pancreatic cancer response to the environmental and treatment input.

Item Type: Article
Uncontrolled Keywords: Animals, Humans, Pancreatic Neoplasms, Antineoplastic Agents, Tissue Engineering, Biomimetics, Tumor Microenvironment
Depositing User: Symplectic Admin
Date Deposited: 19 Feb 2020 14:46
Last Modified: 12 Oct 2023 13:50
DOI: 10.1016/j.drudis.2017.01.012
Open Access URL: http://epubs.surrey.ac.uk/813320/
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3008073