M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.

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Cole, SL, Dunning, J, Kok, WL, Benam, KH, Benlahrech, A, Repapi, E, Martinez, FO, Drumright, L, Powell, TJ, Bennett, M et al (show 12 more authors) , Elderfield, R, Thomas, C, Dong, T, McCauley, J, Liew, FY, Taylor, S, Zambon, M, Barclay, W, Cerundolo, V, Openshaw, PJ, McMichael, AJ and Ho, L-P (2017) M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. JCI Insight, 2 (7). ISSN 2379-3708

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Abstract

In each influenza season, a distinct group of young, otherwise healthy individuals with no risk factors succumbs to life-threatening infection. To better understand the cause for this, we analyzed a broad range of immune responses in blood from a unique cohort of patients, comprising previously healthy individuals hospitalized with and without respiratory failure during one influenza season, and infected with one specific influenza A strain. This analysis was compared with similarly hospitalized influenza patients with known risk factors (total of n = 60 patients recruited). We found a sustained increase in a specific subset of proinflammatory monocytes, with high TNF-α expression and an M1-like phenotype (independent of viral titers), in these previously healthy patients with severe disease. The relationship between M1-like monocytes and immunopathology was strengthened using murine models of influenza, in which severe infection generated using different models (including the high-pathogenicity H5N1 strain) was also accompanied by high levels of circulating M1-like monocytes. Additionally, a raised M1/M2 macrophage ratio in the lungs was observed. These studies identify a specific subtype of monocytes as a modifiable immunological determinant of disease severity in this subgroup of severely ill, previously healthy patients, offering potential novel therapeutic avenues.

Item Type:	Article
Depositing User:	Symplectic Admin
Date Deposited:	30 Jun 2017 12:55
Last Modified:	19 Jan 2023 07:01
DOI:	10.1172/jci.insight.91868
Open Access URL:	https://insight.jci.org/articles/view/91868/pdf
Related URLs:	https://www.ncbi.nlm.nih.gov/pubmed/2840...
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3008270

Available Versions of this Item

• M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. (deposited 30 Jun 2017 12:55) [Currently Displayed]
  • M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. (deposited 06 Sep 2017 15:20)