Liptrott, Neill J ORCID: 0000-0002-5980-8966, Giardiello, Marco ORCID: 0000-0003-0560-4711, McDonald, Tom O ORCID: 0000-0002-9273-9173, Rannard, Steven P ORCID: 0000-0002-6946-1097 and Owen, Andrew ORCID: 0000-0002-9819-7651
(2017)
Lack of interaction of lopinavir solid drug nanoparticles with cells of the immune system.
NANOMEDICINE, 12 (17).
pp. 2043-2054.
Text
2017 LPV SDN v6-NANOMED formatting_revised-2.pdf - Author Accepted Manuscript Download (1MB) |
Abstract
<h4>Aim</h4>We previously demonstrated that solid drug nanoparticles (SDNs) lopinavir (LPV) dispersed into aqueous media display favorable pharmacokinetics.<h4>Methods</h4>The impact of LPV SDNs on the function and phenotype of primary human T cells and macrophages (primary sites of HIV replication) was investigated.<h4>Results</h4>LPV significantly increased IL-1β (ninefold higher than untreated cells; p = 0.045) and TNF-α (sixfold higher than untreated cells; p = 0.018) secretion from monocyte-derived macrophages, whereas LPV SDNs did not elicit these responses at comparable drug concentrations. LPV SDNs were demonstrated to be immunologically inert to human T cells and monocyte-derived macrophages.<h4>Conclusion</h4>The LPV SDN was demonstrated to exhibit comparable, or favorable behavior compared with an LPV aqueous solution in the employed biocompatibility assessments.
Item Type: | Article |
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Uncontrolled Keywords: | antiretroviral nanoformulation, immunotoxicology, macrophages, T cells |
Depositing User: | Symplectic Admin |
Date Deposited: | 07 Jul 2017 07:34 |
Last Modified: | 19 Jan 2023 07:00 |
DOI: | 10.2217/nnm-2017-0095 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3008361 |