Cannabis-related hippocampal volumetric abnormalities specific to subregions in dependent users



Chye, Yann, Suo, Chao, Yucel, Murat, Ouden, Lauren den, Solowij, Nadia and Lorenzetti, Valentina ORCID: 0000-0002-5917-7068
(2017) Cannabis-related hippocampal volumetric abnormalities specific to subregions in dependent users. PSYCHOPHARMACOLOGY, 234 (14). pp. 2149-2157.

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Abstract

<h4>Rationale</h4>Cannabis use is associated with neuroanatomical alterations in the hippocampus. While the hippocampus is composed of multiple subregions, their differential vulnerability to cannabis dependence remains unknown.<h4>Objectives</h4>The objective of the study is to investigate gray matter alteration in each of the hippocampal subregions (presubiculum, subiculum, cornu ammonis (CA) subfields CA1-4, and dentate gyrus (DG)) as associated with cannabis use and dependence.<h4>Methods</h4>A total of 35 healthy controls (HC), 22 non-dependent (CB-nondep), and 39 dependent (CB-dep) cannabis users were recruited. We investigated group differences in hippocampal subregion volumes between HC, CB-nondep, and CB-dep users. We further explored the association between CB use variables (age of onset of regular use, monthly use, lifetime use) and hippocampal subregions in CB-nondep and CB-dep users separately.<h4>Results</h4>The CA1, CA2/3, CA4/DG, as well as total hippocampal gray matter were reduced in volume in CB-dep but not in CB-nondep users, relative to HC. The right CA2/3 and CA4/DG volumes were also negatively associated with lifetime cannabis use in CB-dep users.<h4>Conclusions</h4>Our results suggest a regionally and dependence-specific influence of cannabis use on the hippocampus. Hippocampal alteration in cannabis users was specific to the CA and DG regions and confined to dependent users.

Item Type: Article
Uncontrolled Keywords: Hippocampus, Cannabis, MRI, Brain imaging, Dependence
Depositing User: Symplectic Admin
Date Deposited: 13 Jul 2017 08:24
Last Modified: 19 Jan 2023 06:59
DOI: 10.1007/s00213-017-4620-y
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3008417