Using pharmacokinetic and pharmacodynamic techniques to optimize dosing of antifungal agents for serious and life-threatening fungal infections


Kovanda, LL ORCID: 0000-0002-4493-4652 (2017) Using pharmacokinetic and pharmacodynamic techniques to optimize dosing of antifungal agents for serious and life-threatening fungal infections. PhD thesis, University of Liverpool.

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Abstract

The aim of this thesis is to describe how the use of pharmacokinetic and pharmacodynamic techniques can provide a better understanding of the optimal use of antimicrobial agents. In vivo animal experimental models and clinical PK-PD datasets for three systemically administered antifungal agents, isavuconazonium sulfate (active moiety isavuconazole), micafungin, and VL-2397, are used to accomplish this goal.

Item Type: Thesis (PhD)
Divisions: Faculty of Health and Life Sciences > Faculty of Health and Life Sciences
Depositing User: Symplectic Admin
Date Deposited: 29 Aug 2018 09:09
Last Modified: 19 Jan 2023 06:58
DOI: 10.17638/03008594
Supervisors:
  • Hope, WW
URI: https://livrepository.liverpool.ac.uk/id/eprint/3008594
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