Santos, Victor S, Gurgel, Ricardo Q, Cavalcante, Sandra MM, Kirby, Andrew, Cafe, Lilian P, Souto, Maria J, Dolabella, Silvio S, de Assis, Matheus R, Fumian, Tulio M, Miagostovich, Marize P et al (show 2 more authors)
(2017)
Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil.
JOURNAL OF CLINICAL VIROLOGY, 88.
pp. 33-38.
Text
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Abstract
<h4>Background</h4>Gastroenteritis is one of the most important causes of morbidity and mortality in children and an important etiological agent is norovirus.<h4>Objective</h4>We describe the occurrence and characteristics of norovirus diarrhoea in children from Sergipe, Northeast-Brazil, over two consecutive periods of three years following rotavirus vaccine introduction.<h4>Study design</h4>A cross sectional hospital-based survey conducted from October-2006 to September-2009 and from July-2011 to January-2013. Acute diarrhoea cases had a stool sample collected and tested for norovirus by RT-PCR and positive samples were sequenced.<h4>Results</h4>In total 280 (19.6%) of 1432 samples were norovirus positive, including 204 (18.3%) of 1113 samples collected during the first period and 76 (23.9%) of 318 collected during the second period. The proportion of children with norovirus infection increased significantly through the second study period (χ<sup>2</sup> for trend=6.7; p=0.009), was more frequent in rotavirus vaccinated and in younger children (p<0.001). Of 280 norovirus-positive specimens, 188 (67.1%) were sequenced. Of these, 12 were genogroup I and 176 genogroup II. The main genotype was GII.4 (149/188, 79.3%), followed by GII.2 (6, 3.2%) and GII.6 (5, 2.6%).<h4>Conclusion</h4>Norovirus annual detection rates increased over the study period. The detection of norovirus was higher among young children.
Item Type: | Article |
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Uncontrolled Keywords: | Norovirus, Diarrhoea, Children, Rotavirus vaccine, Brazil |
Depositing User: | Symplectic Admin |
Date Deposited: | 01 Aug 2017 08:46 |
Last Modified: | 19 Jan 2023 06:58 |
DOI: | 10.1016/j.jcv.2016.10.015 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3008714 |