Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury

Usui, Toru, Whitaker, Paul, Meng, Xiaoli ORCID: 0000-0002-7774-2075, Watson, John, Antoine, Daniel J, French, Neil S ORCID: 0000-0002-9376-3482, Park, B Kevin ORCID: 0000-0001-8384-824X and Naisbitt, Dean J (2016) Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29 (11). pp. 1793-1795.

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Official URL: http://dx.doi.org/10.1021/acs.chemrestox.6b00393

Abstract

Antituberculosis (TB) drug exposure is associated with a mild elevation of liver enzymes that occasionally develops into severe liver injury. Herein, we identify ethambutol- and rifampicin-specific CD4+ and CD8+ T-cell clones in a patient with fatal anti TB-related liver injury. The clones were activated to proliferate and secrete IFN-γ, Il-13, and granzyme B following drug treatment. Drug-responsive T-cells may contribute to the pathogenesis of antituberculosis-related liver failure.

Item Type:	Article
Uncontrolled Keywords:	T-Lymphocytes, Humans, Tuberculosis, Pulmonary, Antitubercular Agents, Fatal Outcome, Middle Aged, Male, Chemical and Drug Induced Liver Injury
Depositing User:	Symplectic Admin
Date Deposited:	11 Aug 2017 10:56
Last Modified:	19 Jan 2023 06:58
DOI:	10.1021/acs.chemrestox.6b00393
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3008919