Treating vitamin D deficiency in children with type I diabetes could improve their glycaemic control

Giri, Dinesh, Pintus, Dona, Burnside, Girvan ORCID: 0000-0001-7398-1346, Ghatak, Atrayee, Mehta, Fulya, Paul, Princy and Senniappan, Senthil (2017) Treating vitamin D deficiency in children with type I diabetes could improve their glycaemic control. BMC Research Notes, 10 (1). 465-.

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Official URL: https://bmcresnotes.biomedcentral.com/articles/10....

Abstract

Background and aims The relationship between vitamin D deficiency and type I DM is an ongoing area of interest. The study aims to identify the prevalence of vitamin D deficiency in children and adolescents with T1DM and to assess the impact of treatment of vitamin D deficiency on their glycaemic control. Methods Retrospective data was collected from 271 children and adolescents with T1DM. The vitamin D deficient (25(OH)D <30 nmol/L) and insufficient (25(OH)D 30–50 nmol/L) patients were treated with 6000 units of cholecalciferol and 400 units of cholecalciferol, once daily for 3 months respectively. HbA1c and 25(OH)D concentrations were measured before and at the end of the vitamin D treatment. Results 14.8% from the whole cohort (n = 271) were vitamin D deficient and 31% were insufficient. Among the children included in the final analysis (n = 73), the mean age and plasma 25(OH)D concentration (±SD) were 7.7 years (±4.4) and 32.2 nmol/l (±8.2) respectively. The mean 25(OH)D concentration post-treatment was 65.3 nmol/l (±9.3). The mean HbA1c (±SD) before and after cholecalciferol was 73.5 mmol/mol (±14.9) and 65 mmol/mol (±11.2) respectively (p < 0.001). Children with higher pre-treatment HbA1c had greater reduction in HbA1c (p < 0.001) and those with lower 25(OH)D concentration showed higher reduction in HbA1c (p = 0.004) after treatment. Conclusions Low 25(OH)D concentrations are fairly prevalent in children and adolescents with T1DM, treatment of which, can potentially improve the glycaemic control.

Item Type:	Article
Uncontrolled Keywords:	Vitamin D deficiency, HbA1C, Type 1 diabetes mellitus
Depositing User:	Symplectic Admin
Date Deposited:	25 Sep 2017 07:16
Last Modified:	19 Jan 2023 06:54
DOI:	10.1186/s13104-017-2794-3
Open Access URL:	https://bmcresnotes.biomedcentral.com/articles/10....
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3009593