A dexamethasone, melphalan, actinomycin-D and cytarabine chemotherapy protocol as a rescue treatment for feline lymphoma

Elliott, J and Finotello, R ORCID: 0000-0002-1932-211X (2018) A dexamethasone, melphalan, actinomycin-D and cytarabine chemotherapy protocol as a rescue treatment for feline lymphoma. VETERINARY AND COMPARATIVE ONCOLOGY, 16 (1). E144-E151.

Text DMAC cats paper FINAL CHANGES.docx - Author Accepted Manuscript Download (90kB)

Abstract

Nineteen cats with relapsed high-grade/large-cell lymphoma were treated with dexamethasone, melphalan, actinomycin-D and cytarabine (DMAC). All cats had received Cyclophosphamide, Vincristine, Prednisolone (COP) as first-line chemotherapy and most cats had received at least 2 prior rescue agents with 14 of 19 having received both epirubicin and lomustine. Five cats (26%) exhibited a response (defined as an improvement or resolution of tumour-associated clinical signs/tumour volume, or complete/partial response) to chemotherapy though no patients received more than 2 cycles of DMAC. Most cats tolerated the protocol well though 3 patients exhibited Veterinary Cooperative Oncology Group (VCOG) grade 4 neutropenia and 1 patient exhibited grade 4 thrombocytopenia. The median progression-free survival and overall survival from starting DMAC were 14 and 17 days respectively. There is still an unmet need for successful rescue chemotherapy protocol for cats with relapsed lymphoma. [Correction added on 02 November 2017, after first online publication: The expansion for the term DMAC was previously incorrect and has been corrected in this current version.].

Item Type:	Article
Uncontrolled Keywords:	chemotherapy, feline, lymphoma, rescue
Depositing User:	Symplectic Admin
Date Deposited:	05 Dec 2017 09:07
Last Modified:	19 Jan 2023 06:52
DOI:	10.1111/vco.12360
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3010455