Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.

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Cortese, Franco, Klokov, Dmitry, Osipov, Andreyan ORCID: 0000-0001-5921-9056, Stefaniak, Jakub ORCID: 0000-0001-9151-4485, Moskalev, Alexey ORCID: 0000-0002-3248-1633, Schastnaya, Jane, Cantor, Charles, Aliper, Alexander, Mamoshina, Polina, Ushakov, Igor et al (show 20 more authors) , Sapetsky, Alex, Vanhaelen, Quentin ORCID: 0000-0002-4611-2046, Alchinova, Irina, Karganov, Mikhail ORCID: 0000-0002-5862-8090, Kovalchuk, Olga, Wilkins, Ruth ORCID: 0000-0002-9621-477X, Shtemberg, Andrey, Moreels, Marjan, Baatout, Sarah ORCID: 0000-0001-8110-751X, Izumchenko, Evgeny, de Magalhães, João Pedro ORCID: 0000-0002-6363-2465, Artemov, Artem V ORCID: 0000-0002-0056-4549, Costes, Sylvain V ORCID: 0000-0002-8542-2389, Beheshti, Afshin ORCID: 0000-0003-4643-531X, Mao, Xiao Wen, Pecaut, Michael J ORCID: 0000-0002-2915-9686, Kaminskiy, Dmitry, Ozerov, Ivan V, Scheibye-Knudsen, Morten ORCID: 0000-0002-6637-1280 and Zhavoronkov, Alex (2018) Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization. Oncotarget, 9 (18). pp. 14692-14722.

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Abstract

While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.

Item Type:	Article
Uncontrolled Keywords:	DNA damage, Mars mission, longevity, radioresistance, space exploration
Depositing User:	Symplectic Admin
Date Deposited:	14 Mar 2018 10:12
Last Modified:	19 Jan 2023 06:38
DOI:	10.18632/oncotarget.24461
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3018995