Hobson, James ORCID: 0000-0003-2551-1774, Edwards, Stephanie ORCID: 0000-0002-4959-0158, Slater, Rebecca, Martin, Phillip, Owen, Andrew ORCID: 0000-0002-9819-7651 and Rannard, SP ORCID: 0000-0002-6946-1097
(2018)
Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems.
RSC Advances, 8 (23).
pp. 12984-12991.
Text
Rannard RSC ADVANCES Manuscript Minor Revisions.docx - Author Accepted Manuscript Download (3MB) |
Abstract
The delivery of drugs to the bloodstream <i>via</i> oral administration may suffer from a number of complications including poor dissolution, first pass metabolism and the active intervention of efflux transporters such as P-glycoproteins; drugs which are efflux substrates may cause considerable problems across many clinical conditions. Here we have employed a branch-polymer stabilised nanoemulsion strategy to create highly robust oil droplets (<i>e.g.</i> peanut oil, castor oil and soybean oil) containing different dissolved antiretroviral drugs used in the daily fight against HIV/AIDS. Although very limited difference in permeation through a Caco-2 gut epithelium model was seen for efavirenz, the permeation of the protease inhibitor lopinavir was considerably higher (approximately 10-fold) when applied to an epithelium monolayer in emulsion form than the control within an aqueous DMSO vehicle. The presented nanoemulsion approach may allow drug-specific permeation improvements for various drug substances.
Item Type: | Article |
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Uncontrolled Keywords: | HIV/AIDS, 5.1 Pharmaceuticals, 5 Development of treatments and therapeutic interventions |
Depositing User: | Symplectic Admin |
Date Deposited: | 04 Apr 2018 09:49 |
Last Modified: | 14 Mar 2024 19:10 |
DOI: | 10.1039/c8ra01944d |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3019776 |