Wanlapakorn, Nasamon, Thongmee, Thanunrat, Vichaiwattana, Preeyaporn, Leuridan, Elke, Vongpunsawad, Sompong and Poovorawan, Yong
(2017)
Antibodies to <i>Bordetella</i> <i>pertussis</i> antigens in maternal and cord blood pairs: a Thai cohort study.
PEERJ, 5 (11).
e4043-.
Text
Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort study.pdf - Published version Download (310kB) |
Abstract
<h4>Background</h4>Pertussis is a vaccine-preventable disease, yet an increasing incidence of pertussis occurs in many countries. Thailand has a long-standing pertussis vaccination policy, therefore most expectant mothers today had received vaccines as children. The resurgence of pertussis among Thai infants in recent years led us to examine the pre-existing antibodies to <i>Bordetella pertussis</i> antigens in a cohort of 90 pregnant women.<h4>Methods</h4>We evaluated the IgG to the Pertussis toxin (PT), filamentous hemagglutinin (FHA) and pertactin (PRN) in maternal and cord blood sera using commercial enzyme-linked immunosorbent assays (ELISA).<h4>Results</h4>When values of >10 IU/ml were accepted as potential protective concentrations, we found that the percentages of unprotected infants were 73.3%, 43.3% and 75.5% for anti-PT, anti-FHA and anti-PRN IgG, respectively.<h4>Discussion</h4>These results may explain the susceptibility for pertussis among newborn infants in Thailand and support the requirement for a pertussis booster vaccine during pregnancy, which may contribute to the passive seroprotection among newborns during the first months of life.
Item Type: | Article |
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Uncontrolled Keywords: | Pertussis, Pregnant, Thai, Antibodies, Bordetella pertussis |
Depositing User: | Symplectic Admin |
Date Deposited: | 21 May 2018 06:40 |
Last Modified: | 13 Oct 2023 21:10 |
DOI: | 10.7717/peerj.4043 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3021568 |