Identification of patients who will not achieve seizure remission within 5 years on AEDs.

Hughes, David M ORCID: 0000-0002-1287-9994, Bonnett, Laura J ORCID: 0000-0002-6981-9212, Czanner, Gabriela, Komárek, Arnošt, Marson, Anthony G and García-Fiñana, Marta (2018) Identification of patients who will not achieve seizure remission within 5 years on AEDs. Neurology.

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Abstract

OBJECTIVE:To identify people with epilepsy who will not achieve a 12-month seizure remission within 5 years of starting treatment. METHODS:The Standard and New Antiepileptic Drug (SANAD) study is the largest prospective study in patients with epilepsy to date. We applied a recently developed multivariable approach to the SANAD dataset that takes into account not only baseline covariates describing a patient's history before diagnosis but also follow-up data as predictor variables. RESULTS:Changes in number of seizures and treatment history were the most informative time-dependent predictors and were associated with history of neurologic insult, epilepsy type, age at start of treatment, sex, and having a first-degree relative with epilepsy. Our model classified 95% of patients. Of those classified, 95% of patients observed not to achieve remission at 5 years were correctly classified (95% confidence interval [CI] 89.5%-100%), with 51% identified by 3 years and 90% within 4 years of follow-up. Ninety-seven percent (95% CI 93.3%-98.8%) of patients observed to achieve a remission within 5 years were correctly classified. Of those predicted not to achieve remission, 76% (95% CI 58.5%-88.2%) truly did not achieve remission (positive predictive value). The predictive model achieved similar accuracy levels via external validation in 2 independent United Kingdom-based datasets. CONCLUSION:Our approach generates up-to-date predictions of the patient's risk of not achieving seizure remission whenever new clinical information becomes available that could influence patient counseling and management decisions.

Item Type:	Article
Depositing User:	Symplectic Admin
Date Deposited:	16 Aug 2018 06:23
Last Modified:	19 Jan 2023 01:28
DOI:	10.1212/wnl.0000000000006564
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3025076