Comparison between SELEX and single-step selection for the identification of bivalent aptamers for thrombin



Wilson, Robert, Bourne, Christian, Chaudhuri, Roy, Gregory, Richard, Kenny, John and Cossins, Andrew ORCID: 0000-0002-0813-5212
(2021) Comparison between SELEX and single-step selection for the identification of bivalent aptamers for thrombin. Angewandte Chemie International Edition, 9 (6). e100572-. (Submitted)

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Abstract

The identification of bivalent aptamers for thrombin by SELEX and single-step selection are compared using next generation (massively parallel) sequencing and motif finding informatics. Results show that similar aptamers are identified by both methods.

Item Type: Article
Additional Information: 35 pages. Date: 2014 (submitted)
Uncontrolled Keywords: Biotechnology, Genetics, Aptamers, Nucleotide, Base Sequence, Catalytic Domain, Computational Biology, High-Throughput Nucleotide Sequencing, Humans, Models, Molecular, Nucleotide Motifs, SELEX Aptamer Technique, Sequence Analysis, DNA, Thrombin
Subjects: ?? QP ??
Divisions: Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 17 Aug 2018 14:24
Last Modified: 14 Mar 2024 22:06
DOI: 10.1371/journal.pone.0100572
URI: https://livrepository.liverpool.ac.uk/id/eprint/3025151

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