Lin, H, Pei, C, Markl, D, Shen, Y ORCID: 0000-0002-8915-1993, Elliott, JA and Axel Zeitler, J
(2018)
Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling.
IET Microwaves, Antennas and Propagation, 12 (11).
pp. 1775-1779.
Text
2018-IET-MAP.pdf - Author Accepted Manuscript Download (725kB) |
Abstract
© The Institution of Engineering and Technology 2018. In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis.
Item Type: | Article |
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Uncontrolled Keywords: | pharmaceuticals, coatings, pharmaceutical industry, ray tracing, mixing, discrete element method, numerical verification, tablet mixing, discrete element modelling, terahertz in-line sensing, film coating thickness, individual pharmaceutical tablets, measurement analysis, cumulative measurements, discrete modelling, tablet pan coater, artificial lab-scale tablet, terahertz in-line measurement modality, off-line measurements, in-line measurements, coating process |
Depositing User: | Symplectic Admin |
Date Deposited: | 14 Nov 2018 08:55 |
Last Modified: | 19 Jan 2023 01:12 |
DOI: | 10.1049/iet-map.2018.5561 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3028788 |