Kamtchum-Tatuene, Joseph 
ORCID: 0000-0002-1041-4202, Al-Bayati, Zaid, Mwandumba, Henry Charles, Solomon, Tom ORCID: 0000-0001-7266-6547, Christmas, Stephen E and Benjamin, Laura A ORCID: 0000-0002-9685-1664
(2018)
Serum concentration of anti-Cytomegalovirus IgG and ischaemic stroke in patients with advanced HIV infection in Malawi.
PLOS ONE, 13 (11).
e0208040-.
Abstract
<h4>Background</h4>Studies in high-income settings have shown association between Cytomegalovirus (CMV) infection and adverse cardiovascular outcome, especially in HIV infection. We aimed to study the association between serum concentration of anti-CMV IgG and ischaemic stroke in HIV-infected Malawians.<h4>Methods</h4>Our sample was derived from a case-control stroke study in Malawi. Serum concentration of anti-CMV IgG was measured using enzyme-linked immunosorbent assay. Multivariable logistic regression was used to study the association between high concentrations of anti-CMV IgG (above the third tertile) and ischaemic stroke while adjusting for cardiovascular risk factors.<h4>Results</h4>Overall, 139 HIV-positive adults (48.2% women; 48 ischaemic stroke cases and 91 controls; median age: 45 years) were included. The median CD4+ count was 136 and 401 cell/mm3 (IQR: [75-278] and [230-533]) in cases and controls, respectively. High concentration of anti-CMV IgG was associated with ischaemic stroke in the univariable model (OR = 2.56 [1.23-5.34]) but not after adjusting for duration of antiretroviral therapy (ART), CD4+ count, and other cardiovascular risk factors (OR = 0.94 [0.29-3.08]). Low CD4+ count was an independent predictor of stroke. There was a negative correlation between serum concentration of anti-CMV IgG and CD4+ count (rho = -0.30, p < 0.001).<h4>Conclusions</h4>High concentration of anti-CMV IgG is not independently associated with ischaemic stroke in HIV-infected Malawians. Larger cohort studies are needed to further investigate the role of humoral response to CMV in the pathophysiology of HIV-associated stroke.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Cytomegalovirus, Cytomegalovirus Infections, HIV Infections, Brain Ischemia, Immunoglobulin G, Antibodies, Viral, Anti-HIV Agents, CD4 Lymphocyte Count, Risk Factors, Case-Control Studies, Adult, Middle Aged, Malawi, Female, Male, Stroke, Coinfection, Immunosuppression Therapy |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 05 Dec 2018 16:24 |
| Last Modified: | 19 Jan 2023 01:09 |
| DOI: | 10.1371/journal.pone.0208040 |
| Open Access URL: | https://doi.org/10.1371/journal.pone.0208040 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3029593 |
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