Cervical dystonia: Normal auditory mismatch negativity and abnormal somatosensory mismatch negativity



Chen, Jui-Cheng, Macerollo, Antonella ORCID: 0000-0003-4322-2706, Sadnicka, Anna, Lu, Min-Kuei, Tsai, Chon-Haw, Korlipara, Prasad, Bhatia, Kailash, Rothwell, John C and Edwards, Mark J
(2018) Cervical dystonia: Normal auditory mismatch negativity and abnormal somatosensory mismatch negativity. CLINICAL NEUROPHYSIOLOGY, 129 (9). pp. 1947-1954.

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Abstract

<h4>Objective</h4>Previous electrophysiological and psychophysical tests have suggested that somatosensory integration is abnormal in dystonia. Here, we hypothesised that this abnormality could relate to a more general deficit in pre-attentive error/deviant detection in patients with dystonia. We therefore tested patients with dystonia and healthy subjects using a mismatch negativity paradigm (MMN), where evoked potentials generated in response to a standard repeated stimulus are subtracted from the responses to a rare "odd ball" stimulus.<h4>Methods</h4>We assessed MMN for somatosensory and auditory stimuli in patients with cervical dystonia and healthy age matched controls.<h4>Results</h4>We found a significant group ∗ oddball type interaction effect (F (1, 34) = 4.5, p = 0.04, ρ<sub>I</sub> = 0.63). A follow up independent t-test for sMMN data, showed a smaller sMMN amplitude in dystonic patients compared to controls (mean difference control-dystonia: -1.0 µV ± 0.3, p < 0.00, t = -3.1). However the amplitude of aMMN did not differ between groups (mean difference control-dystonia: -0.2 µV ± 0.2, p = 0.24, t = -1.2). We found a positive correlation between somatosensory MMN and somatosensory temporal discrimination threshold.<h4>Conclusion</h4>These results suggest that pre-attentive error/deviant detection, specifically in the somatosensory domain, is abnormal in dystonia. This could underlie some previously reported electrophysiological and psychophysical abnormalities of somatosensory integration in dystonia.<h4>Significance</h4>One could hypothesize a deficit in pre-conscious orientation towards potentially salient signals might lead to a more conservative threshold for decision-making in dystonia.

Item Type: Article
Uncontrolled Keywords: Mismatch negativity (MMN), Dystonia, Somatosensory integration
Depositing User: Symplectic Admin
Date Deposited: 23 Jan 2019 16:28
Last Modified: 19 Jan 2023 01:08
DOI: 10.1016/j.clinph.2018.05.028
Open Access URL: http://discovery.ucl.ac.uk/10056010/
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3030456