Palladium-Catalyzed Synthesis of Bis-Substituted Sulfoxonium Ylides



Janot, Christopher, Palamini, Pierre, Dobson, Benjamin C, Muir, James and Aissa, Christophe ORCID: 0000-0003-0750-9435
(2019) Palladium-Catalyzed Synthesis of Bis-Substituted Sulfoxonium Ylides. ORGANIC LETTERS, 21 (1). pp. 296-299.

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Abstract

The lack of general access to bis-substituted sulfoxonium ylides is addressed by developing a palladium-catalyzed C-H cross-coupling of α-ester sulfoxonium ylides with (hetero)aryl iodides, bromides, and triflates. Three different catalysts have been evaluated. This method is amenable to the late-stage functionalization of active pharmaceutical ingredients.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 25 Jan 2019 10:17
Last Modified: 19 Jan 2023 01:08
DOI: 10.1021/acs.orglett.8b03744
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3030783