Merga, YJ, O Hara, A, Burkitt, MD ORCID: 0000-0002-5055-6408, Duckworth, CA ORCID: 0000-0001-9992-7540, Probert, CS ORCID: 0000-0003-4550-0239, Campbell, BJ ORCID: 0000-0002-7407-012X and Pritchard, DM ORCID: 0000-0001-7971-3561
(2016)
Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis.
American Journal of Physiology - Gastrointestinal and Liver Physiology, 310 (11).
G1081-G1090.
This is the latest version of this item.
Text
Final Submission combined.pdf - Author Accepted Manuscript Download (753kB) |
Abstract
© 2016 the American Physiological Society.Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett’s esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-κB signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-κB signaling pathway also exerts a distinct influence on these processes. This review brings together current knowledge of the role of the alternative NF-κB signaling pathway in the gastrointestinal tract, with a particular emphasis on inflammation-associated cancer development.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | nuclear factor-kappa B, gastric cancer, Helicobacter pylori, colitis |
Depositing User: | Symplectic Admin |
Date Deposited: | 04 Jan 2019 15:09 |
Last Modified: | 22 Feb 2023 02:09 |
DOI: | 10.1152/ajpgi.00026.2016 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3030794 |
Available Versions of this Item
-
Importance of the alternative NF-kappa B activation pathway in inflammation-associated gastrointestinal carcinogenesis. (deposited 04 May 2016 10:50)
- Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis. (deposited 04 Jan 2019 15:09) [Currently Displayed]