Viperin Poisons Viral Replication

Ng, Lisa FP ORCID: 0000-0003-4071-5222 and Hiscox, Julian A ORCID: 0000-0002-6582-0275 (2018) Viperin Poisons Viral Replication. CELL HOST & MICROBE, 24 (2). pp. 181-183.

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Official URL: http://dx.doi.org/10.1016/j.chom.2018.07.014

Abstract

Control of virus infection relies on the stimulation of interferon-stimulated genes (ISGs) that inhibit viral replication. In a recent Nature paper, Gizzi et al. (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering insights into drug design.

Item Type:	Article
Uncontrolled Keywords:	Humans, Proteins, Ribonucleotides, Antiviral Agents, Poisons, Virus Replication, Genome, Human
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	17 Jun 2021 13:40
Last Modified:	19 Jan 2023 01:06
DOI:	10.1016/j.chom.2018.07.014
Open Access URL:	https://www.cell.com/cell-host-microbe/fulltext/S1...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3031737