New insights into the biomechanics of Legg-Calve-Perthes' disease

Pinheiro, M, Dobson, CA, Perry, D ORCID: 0000-0001-8420-8252 and Fagan, MJ (2018) New insights into the biomechanics of Legg-Calve-Perthes' disease. BONE & JOINT RESEARCH, 7 (2). pp. 148-156.

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Official URL: http://dx.doi.org/10.1302/2046-3758.72.bjr-2017-01...

Abstract

<h4>Objectives</h4>Legg-Calvé-Perthes' disease (LCP) is an idiopathic osteonecrosis of the femoral head that is most common in children between four and eight years old. The factors that lead to the onset of LCP are still unclear; however, it is believed that interruption of the blood supply to the developing epiphysis is an important factor in the development of the condition.<h4>Methods</h4>Finite element analysis modelling of the blood supply to the juvenile epiphysis was investigated to understand under which circumstances the blood vessels supplying the femoral epiphysis could become obstructed. The identification of these conditions is likely to be important in understanding the biomechanics of LCP.<h4>Results</h4>The results support the hypothesis that vascular obstruction to the epiphysis may arise when there is delayed ossification and when articular cartilage has reduced stiffness under compression.<h4>Conclusion</h4>The findings support the theory of vascular occlusion as being important in the pathophysiology of Perthes disease.<b>Cite this article</b>: M. Pinheiro, C. A. Dobson, D. Perry, M. J. Fagan. New insights into the biomechanics of Legg-Calvé-Perthes' disease: The Role of Epiphyseal Skeletal Immaturity in Vascular Obstruction. <i>Bone Joint Res</i> 2018;7:148-156. DOI: 10.1302/2046-3758.72.BJR-2017-0191.R1.

Item Type:	Article
Uncontrolled Keywords:	Perthes' disease, Vessel obstruction, Juvenile hip, Biomechanics, Finite element analysis
Depositing User:	Symplectic Admin
Date Deposited:	30 Jan 2019 11:17
Last Modified:	14 Mar 2024 22:22
DOI:	10.1302/2046-3758.72.BJR-2017-0191.R1
Open Access URL:	https://doi.org/10.1302/2046-3758.72.BJR-2017-0191...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3032001