Negoita, Madalina, Hughes, Alun D 
ORCID: 0000-0001-5432-5271, Parker, Kim H and Khir, Ashraf W
(2018)
A method for determining local pulse wave velocity in human ascending aorta from sequential ultrasound measurements of diameter and velocity.
Physiological measurement, 39 (11).
p. 114009.
Abstract
BACKGROUND:Pulse wave velocity (PWV) is an indicator of arterial stiffness, and predicts cardiovascular events independently of blood pressure. Currently, PWV is commonly measured by the foot-to-foot technique thus giving a global estimate of large arterial stiffness. However, and despite its importance, methods to measure the stiffness of the ascending aorta are limited. OBJECTIVE:To introduce a method for calculating local PWV in the human ascending aorta using non-invasive ultrasound measurements of its diameter (D) and flow velocity (U). APPROACH:Ten participants (four females) were recruited from Brunel University students. Ascending aortic diameter and velocity were recorded with a GE Vivid E95 equipped with a 1.5-4.5 MHz phased array transducer using M-mode in the parasternal long axis view and pulse wave Doppler in the apical five chamber view respectively. Groups of six consecutive heartbeats were selected from each 20 s run based on the most similar cycle length resulting in three groups for D and three for U each with six waveforms. Each D waveform was paired with each U waveform to calculate PWV using ln(D)U-loop method. MAIN RESULTS:The diastolic portions of the diameters or velocities waveforms were truncated to allow the pairs to have equal length and were used to construct ln(D)U-loops. The trimmed average, excluding 10% of extreme values, resulting from the 324 loops was considered representative for each participant. Overall mean local PWV for all participants was 4.1(SD = 0.9) m s-1. SIGNIFICANCE:Local PWV can be measured non-invasively in the ascending aorta using ultrasound measurements of diameter and flow velocity This should facilitate more widespread assessment of ascending aortic stiffness in larger studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Aorta, Humans, Ultrasonography, Systole, Adult, Female, Male, Young Adult, Pulse Wave Analysis |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 05 Feb 2019 16:27 |
| Last Modified: | 19 Jan 2023 01:05 |
| DOI: | 10.1088/1361-6579/aae8a0 |
| Open Access URL: | https://doi.org/10.1088/1361-6579/aae8a0 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3032305 |
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