New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries



Shrine, Nick, Guyatt, Anna L, Erzurumluoglu, A Mesut, Jackson, Victoria E, Hobbs, Brian D, Melbourne, Carl A, Batini, Chiara, Fawcett, Katherine A, Song, Kijoung, Sakornsakolpat, Phuwanat
et al (show 99 more authors) (2019) New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. NATURE GENETICS, 51 (3). 481-+.

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Abstract

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function-associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.

Item Type: Article
Uncontrolled Keywords: Understanding Society Scientific Group, Lung, Humans, Pulmonary Disease, Chronic Obstructive, Genetic Predisposition to Disease, Risk Factors, Case-Control Studies, Smoking, Polymorphism, Single Nucleotide, Aged, Aged, 80 and over, Middle Aged, Female, Male, Genome-Wide Association Study
Depositing User: Symplectic Admin
Date Deposited: 15 Mar 2019 14:37
Last Modified: 19 Jan 2023 01:01
DOI: 10.1038/s41588-018-0321-7
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3033494